Tamoxifen Citrate sold as Nolvadex and many others is classified as a Selective Estrogen Receptor Modulator (SERM). Therefore, the compound is working as an estrogen antagonist in some parts of the body. But at the same time, Tamoxifen is working as an estrogen agonist. It means that the compound is going to increase the estrogen activity as soon as it binds to it.
Based on this – you can better understand the side effects of Tamoxifen. Despite the fact that the side effects are not anything too bad – you should still be very aware of the possible negative side effects of Tamoxifen.
- Mostly, side effects appear when the compound is used in too large doses. And other times when the individual is having an abnormally low tolerance to the compound.
Nonetheless, for most people, Tamoxifen side effects are very tolerable, especially for men because men are much less likely to get side effects compared to women.
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So, you should better understand how Nolvadex works for a better understanding of the side effects.
Tamoxifen Side Effects
As mentioned, Tamoxifen is working by blocking estrogenic activity by binding to estrogen receptors in different parts of the body. But it works the other way around (boosting estrogenic activity) in other parts of your body. One example is estrogen activity increase in the liver.
This leads to various issues. One of them is that Tamoxifen can be liver damage. Nonetheless, studies prove that you need to use huge doses and/ or for a very long period to make Tamoxifen Citrate damaging to the liver.
- Nonetheless, because of the way it works in the liver – Tamoxifen Citrate is increasing levels of SHGB – Sex Hormone Binding Globulin. Professional bodybuilders already know how big of a problem is that.
SHBG is lowering free testosterone levels in the body and this is the amount of the testosterone that is floating in the body not being bound to the system. This is the level of testosterone (free testosterone) that is having an extremely close relationship to the positive effects of high testosterone that we know. For example, increased libido, increased muscle mass, and strength.
This is the reason why people who use Tamoxifen Citrate might complain of decreased libido. But since Tamoxifen is known to increase levels of testosterone production (that’s why it is used for PCT plans) – many people notice a huge increase in their libido.
The negative part of lowering free testosterone as a result of increased SHBG – is not only in libido loss. But it may also hurt the gains of muscle mass and strength.
Explaining Tamoxifen Side Effects
But except for lowering free testosterone, another side effect of Tamoxifen is the fact that it also lowers the powerful peptide hormone IGF-1 due to its actions on the liver. That’s an extremely powerful growth hormone – needless to mention that is essential for the purpose of building muscle tissues and growing muscles.
People who are having lots of IGF-1 levels are capable of growing muscles way faster and way efficiently – allowing them for a much better bodybuilding process. Yet, Tamoxifen Citrate (Nolvadex) might suppress the levels of IGF-1 which is a big issue for bodybuilders.
- When Tamoxifen is used for medical purposes, other side effects may be displayed in the literature.
But that’s because women are reacting differently than men to Nolvadex.
But since we’re talking about the side effects of Tamoxifen specifically about bodybuilding purposes for men – we share the most common and most problematic side effects for men.
So, except for a decrease of IGF-1 levels and free testosterone as well as potentially decreased libido There are others. Side effects that are possible include blood clots, liver damage, and progesterone related issues. That’s since Nolvadex is upregulating progestin.
Nonetheless, all of these side effects are very unlikely to appear. Especially if using Tamoxifen in normal doses for a normal amount of time.
Tamoxifen side effects that are most common include: mood swings – a lot of bodybuilders are reporting feeling emotional, having often and annoying mood swings and sometimes even depression; nausea, diarrhea; vomiting; fatigue, and others.
Conclusion
Nonetheless, the side effects are still not too likely to appear. Remember that Tamoxifen is used by bodybuilders to prevent side effects. Either for gynecomastia control during the use of steroids or most likely – for Post Cycle Therapy (PCT) needs.
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